Drug interactions
Sertraline + Tezacaftor
Severity: Minor
Sertraline and Tezacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A4 substrate, and sertraline is only a weak CYP3A4 inhibitor, so a clinically meaningful rise in exposure is unlikely. Tezacaftor is given with ivacaftor, whose exposure could also rise slightly.
What this interaction means in plain words
Sertraline and Tezacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly reduce tezacaftor clearance.
What to do
No routine dose adjustment is needed. Monitor for tezacaftor/ivacaftor adverse effects such as headache and nausea, and check liver tests as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Tezacaftor?
MediHelp rates the interaction as minor. Sertraline and Tezacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tezacaftor is a CYP3A4 substrate, and sertraline is only a weak CYP3A4 inhibitor, so a clinically meaningful rise in exposure is unlikely. Tezacaftor is given with ivacaftor, whose exposure could also rise slightly.
How serious is the interaction between Sertraline and Tezacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor for tezacaftor/ivacaftor adverse effects such as headache and nausea, and check liver tests as usual.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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