Drug interactions
Sertraline + Tofacitinib
Severity: Minor
Sertraline and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is at most a weak CYP3A4 and CYP2C19 inhibitor at usual doses, so a clinically meaningful rise in tofacitinib exposure is unlikely. Any effect is probably small.
What this interaction means in plain words
Sertraline and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak inhibition of CYP3A4 and CYP2C19 by sertraline may slightly reduce tofacitinib clearance.
What to do
No dose adjustment is needed. Monitor for tofacitinib adverse effects such as infections and cytopenias as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Tofacitinib?
MediHelp rates the interaction as minor. Sertraline and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is at most a weak CYP3A4 and CYP2C19 inhibitor at usual doses, so a clinically meaningful rise in tofacitinib exposure is unlikely. Any effect is probably small.
How serious is the interaction between Sertraline and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for tofacitinib adverse effects such as infections and cytopenias as usual.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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