Drug interactions
Sertraline + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Sertraline and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta agonist, can increase heart rate and affect QT, and sertraline has a modest QT effect. Systemic exposure from inhalation is low, so the clinical effect is usually small.
What this interaction means in plain words
Sertraline and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Potential additive effects on cardiac repolarization from beta-agonist action and sertraline.
What to do
No routine change is needed. Use caution in patients with known QT prolongation or arrhythmia and report palpitations or syncope.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Sertraline and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol, a long-acting beta agonist, can increase heart rate and affect QT, and sertraline has a modest QT effect. Systemic exposure from inhalation is low, so the clinical effect is usually small.
How serious is the interaction between Sertraline and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Use caution in patients with known QT prolongation or arrhythmia and report palpitations or syncope.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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