Drug interactions
Sildenafil + Vericiguat
Severity: Contraindicated
Sildenafil and Vericiguat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vericiguat stimulates soluble guanylate cyclase and sildenafil blocks cGMP breakdown, so together they may cause additive hypotension. Concurrent use with PDE5 inhibitors is not recommended in labeling.
What this interaction means in plain words
Sildenafil and Vericiguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Sildenafil belongs to Genitourinary; Vericiguat belongs to Cardiovascular.
Why it happens
Increased cGMP production from soluble guanylate cyclase stimulation combined with reduced cGMP degradation by PDE5 inhibition leads to additive vasodilation.
What to do
Avoid concurrent use of sildenafil and vericiguat. Choose an alternative for erectile dysfunction or pulmonary hypertension while on vericiguat.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Vericiguat
- Avanafil + Vericiguat Contraindicated
- Tadalafil + Vericiguat Contraindicated
- Vardenafil + Vericiguat Contraindicated
Frequently asked questions
Can I take Sildenafil with Vericiguat?
MediHelp rates the interaction as contraindicated. Sildenafil and Vericiguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vericiguat stimulates soluble guanylate cyclase and sildenafil blocks cGMP breakdown, so together they may cause additive hypotension. Concurrent use with PDE5 inhibitors is not recommended in labeling.
How serious is the interaction between Sildenafil and Vericiguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of sildenafil and vericiguat. Choose an alternative for erectile dysfunction or pulmonary hypertension while on vericiguat.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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