Drug interactions
Avanafil + Vericiguat
Severity: Contraindicated
Avanafil and Vericiguat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vericiguat with avanafil may cause additive hypotension with dizziness or syncope. Concomitant use with PDE5 inhibitors is not recommended in labeling.
What this interaction means in plain words
Avanafil and Vericiguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Vericiguat belongs to Cardiovascular.
Why it happens
Soluble guanylate cyclase stimulation and PDE5 inhibition both increase cGMP, giving additive vasodilation.
What to do
Avoid the combination; reassess need for either drug. If exposure occurs, monitor blood pressure and symptoms of hypotension.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Vericiguat
- Sildenafil + Vericiguat Contraindicated
- Tadalafil + Vericiguat Contraindicated
- Vardenafil + Vericiguat Contraindicated
Frequently asked questions
Can I take Avanafil with Vericiguat?
MediHelp rates the interaction as contraindicated. Avanafil and Vericiguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vericiguat with avanafil may cause additive hypotension with dizziness or syncope. Concomitant use with PDE5 inhibitors is not recommended in labeling.
How serious is the interaction between Avanafil and Vericiguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; reassess need for either drug. If exposure occurs, monitor blood pressure and symptoms of hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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