Drug interactions
Tadalafil + Vericiguat
Severity: Contraindicated
Tadalafil and Vericiguat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vericiguat with tadalafil may cause additive blood pressure reduction and symptomatic hypotension. Labeling advises against concomitant use of vericiguat with PDE5 inhibitors.
What this interaction means in plain words
Tadalafil and Vericiguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Tadalafil belongs to Genitourinary; Vericiguat belongs to Cardiovascular.
Why it happens
Soluble guanylate cyclase stimulation by vericiguat increases cGMP while PDE5 inhibition slows its degradation, producing additive vasodilation.
What to do
Avoid concomitant use; if tadalafil is required, reconsider vericiguat therapy. Monitor blood pressure and for dizziness if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Vericiguat
- Avanafil + Vericiguat Contraindicated
- Sildenafil + Vericiguat Contraindicated
- Vardenafil + Vericiguat Contraindicated
Frequently asked questions
Can I take Tadalafil with Vericiguat?
MediHelp rates the interaction as contraindicated. Tadalafil and Vericiguat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vericiguat with tadalafil may cause additive blood pressure reduction and symptomatic hypotension. Labeling advises against concomitant use of vericiguat with PDE5 inhibitors.
How serious is the interaction between Tadalafil and Vericiguat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; if tadalafil is required, reconsider vericiguat therapy. Monitor blood pressure and for dizziness if exposure occurs.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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