Drug interactions
Siponimod + Trabectedin
Severity: Moderate
Siponimod and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin commonly causes neutropenia and other cytopenias. Siponimod's lymphocyte-lowering effect may add to infection risk.
What this interaction means in plain words
Siponimod and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siponimod belongs to Central Nervous System; Trabectedin belongs to Oncology.
Why it happens
Additive immunosuppression from cytotoxic myelosuppression and S1P receptor-mediated lymphocyte sequestration.
What to do
Monitor complete blood counts and for infection. Follow trabectedin dose-modification guidance for neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Trabectedin
Frequently asked questions
Can I take Siponimod with Trabectedin?
MediHelp rates the interaction as moderate. Siponimod and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin commonly causes neutropenia and other cytopenias. Siponimod's lymphocyte-lowering effect may add to infection risk.
How serious is the interaction between Siponimod and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for infection. Follow trabectedin dose-modification guidance for neutropenia.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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