Drug interactions
Sipuleucel-t + Ustekinumab
Severity: Moderate
Sipuleucel-t and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sipuleucel-T depends on a functioning immune response. Immunosuppressants such as ustekinumab could in theory reduce its effect.
What this interaction means in plain words
Sipuleucel-t and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression may impair immune activation targeted by sipuleucel-T; this is a predicted effect.
What to do
Avoid immunosuppressants around leukapheresis and infusion where possible. If ustekinumab is necessary, review expected benefit with the treating oncologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Sipuleucel-t with Ustekinumab?
MediHelp rates the interaction as moderate. Sipuleucel-t and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sipuleucel-T depends on a functioning immune response. Immunosuppressants such as ustekinumab could in theory reduce its effect.
How serious is the interaction between Sipuleucel-t and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid immunosuppressants around leukapheresis and infusion where possible. If ustekinumab is necessary, review expected benefit with the treating oncologist.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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