Drug interactions
Sitagliptin + Tenofovir df
Severity: Minor
Sitagliptin and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo renal elimination, and tenofovir nephrotoxicity could reduce sitagliptin clearance, raising its levels. Sitagliptin dosing depends on renal function, so declining kidney function matters.
What this interaction means in plain words
Sitagliptin and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular secretion and tenofovir-related renal impairment reducing sitagliptin clearance.
What to do
Monitor renal function periodically and adjust sitagliptin dose according to eGFR.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Sitagliptin with Tenofovir df?
MediHelp rates the interaction as minor. Sitagliptin and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs undergo renal elimination, and tenofovir nephrotoxicity could reduce sitagliptin clearance, raising its levels. Sitagliptin dosing depends on renal function, so declining kidney function matters.
How serious is the interaction between Sitagliptin and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and adjust sitagliptin dose according to eGFR.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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