Drug interactions
Sitagliptin + Xipamide
Severity: Minor
Sitagliptin and Xipamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics such as xipamide can modestly raise blood glucose, potentially reducing the glycemic control of sitagliptin. An effect on sitagliptin renal clearance is not established.
What this interaction means in plain words
Sitagliptin and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Diuretic-related impaired glucose tolerance (e.g. via hypokalemia); a renal clearance effect is unproven.
What to do
Monitor blood glucose and potassium when starting or adjusting xipamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Sitagliptin with Xipamide?
MediHelp rates the interaction as minor. Sitagliptin and Xipamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-like diuretics such as xipamide can modestly raise blood glucose, potentially reducing the glycemic control of sitagliptin. An effect on sitagliptin renal clearance is not established.
How serious is the interaction between Sitagliptin and Xipamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or adjusting xipamide.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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