Drug interactions
Sodium citrate / citric acid + Tolbutamide
Severity: Minor
Sodium citrate / citric acid and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sodium citrate/citric acid raises gastric pH and is metabolized to bicarbonate, which can alkalinize urine. Any change in tolbutamide exposure is expected to be small and of limited clinical relevance.
What this interaction means in plain words
Sodium citrate / citric acid and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Altered gastric and urinary pH may slightly change tolbutamide absorption and renal elimination; the effect is theoretical.
What to do
No dose adjustment is usually needed; monitor blood glucose if the alkalinizing agent is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Sodium citrate / citric acid with Tolbutamide?
MediHelp rates the interaction as minor. Sodium citrate / citric acid and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral sodium citrate/citric acid raises gastric pH and is metabolized to bicarbonate, which can alkalinize urine. Any change in tolbutamide exposure is expected to be small and of limited clinical relevance.
How serious is the interaction between Sodium citrate / citric acid and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood glucose if the alkalinizing agent is used regularly.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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