Drug interactions
Sodium picosulfate / magnesium oxide / anhydrous citric acid + Sulindac
Severity: Moderate
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion in volume depletion. The combination raises the risk of acute kidney injury.
What this interaction means in plain words
Sodium picosulfate / magnesium oxide / anhydrous citric acid and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from osmotic catharsis combined with NSAID inhibition of prostaglandin-mediated renal blood flow.
What to do
Hold sulindac before and during bowel preparation where feasible, maintain hydration, and check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sodium picosulfate / magnesium oxide / anhydrous citric acid with Sulindac?
MediHelp rates the interaction as moderate. Sodium picosulfate / magnesium oxide / anhydrous citric acid and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion in volume depletion. The combination raises the risk of acute kidney injury.
How serious is the interaction between Sodium picosulfate / magnesium oxide / anhydrous citric acid and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold sulindac before and during bowel preparation where feasible, maintain hydration, and check renal function and electrolytes in high-risk patients.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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