Drug interactions
Sodium sulfate / ?magnesium sulfate / potassium chloride + Sulindac
Severity: Moderate
Sodium sulfate / ?magnesium sulfate / potassium chloride and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause dehydration and electrolyte disturbances, and NSAIDs may worsen renal injury in this setting. Seizures, arrhythmias and renal impairment are potential consequences.
What this interaction means in plain words
Sodium sulfate / ?magnesium sulfate / potassium chloride and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluid and electrolyte depletion combined with NSAID reduction of renal prostaglandin-dependent perfusion.
What to do
Avoid sulindac around the preparation period where possible, ensure adequate fluid intake, and check electrolytes and renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sodium sulfate / ?magnesium sulfate / potassium chloride with Sulindac?
MediHelp rates the interaction as moderate. Sodium sulfate / ?magnesium sulfate / potassium chloride and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause dehydration and electrolyte disturbances, and NSAIDs may worsen renal injury in this setting. Seizures, arrhythmias and renal impairment are potential consequences.
How serious is the interaction between Sodium sulfate / ?magnesium sulfate / potassium chloride and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sulindac around the preparation period where possible, ensure adequate fluid intake, and check electrolytes and renal function in at-risk patients.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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