Drug interactions
Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol + Sulindac
Severity: Moderate
Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can promote water retention and affect sodium handling, and bowel preparations cause large fluid and electrolyte shifts. Together they may increase the risk of hyponatremia and renal impairment.
What this interaction means in plain words
Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related impairment of renal water excretion and perfusion combined with preparation-induced fluid and electrolyte changes.
What to do
Avoid sulindac during bowel preparation if possible and encourage appropriate fluid intake; check sodium and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol with Sulindac?
MediHelp rates the interaction as moderate. Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can promote water retention and affect sodium handling, and bowel preparations cause large fluid and electrolyte shifts. Together they may increase the risk of hyponatremia and renal impairment.
How serious is the interaction between Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sulindac during bowel preparation if possible and encourage appropriate fluid intake; check sodium and renal function in high-risk patients.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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