Drug interactions
Sodium sulfate / potassium sulfate / magnesium sulfate + Sulindac
Severity: Moderate
Sodium sulfate / potassium sulfate / magnesium sulfate and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte shifts, and NSAIDs can aggravate renal injury during volume depletion. This raises the risk of renal impairment and electrolyte-related events.
What this interaction means in plain words
Sodium sulfate / potassium sulfate / magnesium sulfate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume and electrolyte depletion from the preparation plus NSAID inhibition of renal prostaglandins.
What to do
Withhold sulindac around the bowel preparation where feasible, ensure hydration, and check renal function and electrolytes in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sodium sulfate / potassium sulfate / magnesium sulfate with Sulindac?
MediHelp rates the interaction as moderate. Sodium sulfate / potassium sulfate / magnesium sulfate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte shifts, and NSAIDs can aggravate renal injury during volume depletion. This raises the risk of renal impairment and electrolyte-related events.
How serious is the interaction between Sodium sulfate / potassium sulfate / magnesium sulfate and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold sulindac around the bowel preparation where feasible, ensure hydration, and check renal function and electrolytes in at-risk patients.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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