Drug interactions
Sofosbuvir-velpatasvir + Valsartan
Severity: Minor
Sofosbuvir-velpatasvir and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits hepatic uptake transporters, which can raise valsartan exposure, since valsartan is an OATP1B1/1B3 substrate. The expected result is a modest increase in valsartan effect, such as lower blood pressure.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir belongs to Anti Virals; Valsartan belongs to Cardiovascular.
Why it happens
Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1, reducing hepatic uptake and clearance of valsartan.
What to do
No dose change is usually required; monitor blood pressure and renal function when starting or stopping the antiviral combination.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Valsartan?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits hepatic uptake transporters, which can raise valsartan exposure, since valsartan is an OATP1B1/1B3 substrate. The expected result is a modest increase in valsartan effect, such as lower blood pressure.
How serious is the interaction between Sofosbuvir-velpatasvir and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor blood pressure and renal function when starting or stopping the antiviral combination.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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