Drug interactions
Sofosbuvir / velpatasvir + Vinblastine
Severity: Minor
Sofosbuvir / velpatasvir and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a P-gp substrate and not a recognized P-gp inducer, so it is unlikely to lower sofosbuvir or velpatasvir exposure. The interaction is theoretical.
What this interaction means in plain words
Sofosbuvir / velpatasvir and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
A P-gp induction effect by vinblastine is not established.
What to do
No dose change is needed. Monitor hepatitis C virologic response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Sofosbuvir / velpatasvir with Vinblastine?
MediHelp rates the interaction as minor. Sofosbuvir / velpatasvir and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinblastine is a P-gp substrate and not a recognized P-gp inducer, so it is unlikely to lower sofosbuvir or velpatasvir exposure. The interaction is theoretical.
How serious is the interaction between Sofosbuvir / velpatasvir and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor hepatitis C virologic response as usual.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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