Drug interactions
Somapacitan + Triamcinolone
Severity: Moderate
Somapacitan and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which can reduce conversion of cortisone to active cortisol and unmask adrenal insufficiency. Supraphysiologic glucocorticoid doses can also blunt the growth-promoting effect of growth hormone.
What this interaction means in plain words
Somapacitan and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Somapacitan belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Growth hormone inhibition of 11-beta-HSD-1 and pharmacodynamic antagonism of growth effects by glucocorticoids.
What to do
Monitor growth response and adjust the somapacitan dose as needed, using the lowest effective glucocorticoid dose. In patients on glucocorticoid replacement, reassess the dose after starting growth hormone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Somapacitan with Triamcinolone?
MediHelp rates the interaction as moderate. Somapacitan and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, which can reduce conversion of cortisone to active cortisol and unmask adrenal insufficiency. Supraphysiologic glucocorticoid doses can also blunt the growth-promoting effect of growth hormone.
How serious is the interaction between Somapacitan and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth response and adjust the somapacitan dose as needed, using the lowest effective glucocorticoid dose. In patients on glucocorticoid replacement, reassess the dose after starting growth hormone.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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