Drug interactions
Somatropin + Tolazamide
Severity: Moderate
Somatropin and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of sulfonylurea therapy such as tolazamide. Patients with diabetes may need higher antidiabetic doses after starting growth hormone.
What this interaction means in plain words
Somatropin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Somatropin belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone decreases insulin sensitivity, opposing the insulin-secretagogue effect of tolazamide.
What to do
Monitor blood glucose closely when somatropin is started or its dose is changed. Titrate tolazamide as needed, and reduce it again if growth hormone is stopped or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Somatropin with Tolazamide?
MediHelp rates the interaction as moderate. Somatropin and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of sulfonylurea therapy such as tolazamide. Patients with diabetes may need higher antidiabetic doses after starting growth hormone.
How serious is the interaction between Somatropin and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when somatropin is started or its dose is changed. Titrate tolazamide as needed, and reduce it again if growth hormone is stopped or reduced.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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