Drug interactions
Somatropin + Warfarin
Severity: Minor
Somatropin and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase hepatic CYP450 activity and could reduce warfarin exposure. The clinical effect is poorly documented.
What this interaction means in plain words
Somatropin and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Somatropin belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Possible induction of CYP-mediated metabolism by growth hormone, theoretically lowering warfarin levels.
What to do
Check INR after starting or changing somatropin and increase warfarin if the INR falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Somatropin with Warfarin?
MediHelp rates the interaction as minor. Somatropin and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase hepatic CYP450 activity and could reduce warfarin exposure. The clinical effect is poorly documented.
How serious is the interaction between Somatropin and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or changing somatropin and increase warfarin if the INR falls.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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