Drug interactions
Sotorasib + Vincristine
Severity: Moderate
Sotorasib and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib may induce P-glycoprotein and CYP3A4, which could lower vincristine exposure. This could reduce vincristine efficacy, though clinical data are limited.
What this interaction means in plain words
Sotorasib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4 and may alter P-glycoprotein transport, potentially lowering vincristine concentrations.
What to do
Monitor for reduced antineoplastic response if combined. Consider alternatives if vincristine efficacy is critical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Vincristine?
MediHelp rates the interaction as moderate. Sotorasib and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib may induce P-glycoprotein and CYP3A4, which could lower vincristine exposure. This could reduce vincristine efficacy, though clinical data are limited.
How serious is the interaction between Sotorasib and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antineoplastic response if combined. Consider alternatives if vincristine efficacy is critical.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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