Drug interactions
Spironolactone + Timolol
Severity: Minor
Spironolactone and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic beta-blockers can modestly raise serum potassium by impairing cellular potassium uptake. Added to spironolactone, this may contribute to hyperkalemia, especially in renal impairment. The effect is usually small.
What this interaction means in plain words
Spironolactone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Spironolactone belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade reduces beta-2 mediated cellular potassium uptake, adding to potassium retention from aldosterone antagonism.
What to do
Monitor serum potassium periodically, particularly in patients with renal impairment or diabetes. No dose change is usually needed if potassium stays normal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Spironolactone with Timolol?
MediHelp rates the interaction as minor. Spironolactone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic beta-blockers can modestly raise serum potassium by impairing cellular potassium uptake. Added to spironolactone, this may contribute to hyperkalemia, especially in renal impairment. The effect is usually small.
How serious is the interaction between Spironolactone and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, particularly in patients with renal impairment or diabetes. No dose change is usually needed if potassium stays normal.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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