Drug interactions
statin + warfarin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Several statins can increase INR in patients on warfarin, raising bleeding risk, especially after statin initiation or dose changes.
Mechanism of action
Unknown; may involve altered warfarin metabolism or protein binding depending on the statin.
Clinical management
When starting or adjusting a statin, check INR within 3–7 days and again after stabilization; adjust warfarin as needed and monitor for bleeding.
Drug reference
References
- ZOCOR (simvastatin) Prescribing Information — FDA Label
- CRESTOR (rosuvastatin) Prescribing Information — FDA Label
- Warfarin: Drug interactions — Lexicomp
Frequently asked questions
Can I take statin with warfarin?
The interaction is rated: Moderate. Several statins can increase INR in patients on warfarin, raising bleeding risk, especially after statin initiation or dose changes.
How serious is the interaction between statin and warfarin?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between statin and warfarin managed?
When starting or adjusting a statin, check INR within 3–7 days and again after stabilization; adjust warfarin as needed and monitor for bleeding.
Why do statin and warfarin interact?
Unknown; may involve altered warfarin metabolism or protein binding depending on the statin.
Full monographs, dosing and an interaction checker in the MediHelp app
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