Drug interactions
Streptomycin + Tolmetin
Severity: Moderate
Streptomycin and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may decrease renal clearance of aminoglycosides, raising streptomycin concentrations and the risk of ototoxicity and nephrotoxicity. Reports mainly involve preterm infants.
What this interaction means in plain words
Streptomycin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Streptomycin belongs to Anti Bacterial; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID-mediated reduction in renal prostaglandins and glomerular filtration decreases aminoglycoside clearance.
What to do
Monitor renal function, streptomycin levels and auditory or vestibular symptoms, and adjust dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Tolmetin?
MediHelp rates the interaction as moderate. Streptomycin and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may decrease renal clearance of aminoglycosides, raising streptomycin concentrations and the risk of ototoxicity and nephrotoxicity. Reports mainly involve preterm infants.
How serious is the interaction between Streptomycin and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, streptomycin levels and auditory or vestibular symptoms, and adjust dosing as needed.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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