Drug interactions
Sufentanil + Topiramate
Severity: Moderate
Sufentanil and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid, and topiramate adds central nervous system depression. Combined use can deepen sedation and, with opioid dosing, may increase the risk of respiratory depression.
What this interaction means in plain words
Sufentanil and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sufentanil belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Monitor sedation level and respiratory rate, and reduce the sufentanil dose if excess sedation occurs. Ensure appropriate monitoring in perioperative or epidural settings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Sufentanil with Topiramate?
MediHelp rates the interaction as moderate. Sufentanil and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a very potent opioid, and topiramate adds central nervous system depression. Combined use can deepen sedation and, with opioid dosing, may increase the risk of respiratory depression.
How serious is the interaction between Sufentanil and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and reduce the sufentanil dose if excess sedation occurs. Ensure appropriate monitoring in perioperative or epidural settings.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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