Drug interactions
Sufentanil + Venlafaxine
Severity: Moderate
Sufentanil and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is an opioid with some serotonergic potential, and serotonin syndrome has been reported with fentanyl-class opioids given with SNRIs. Additive sedation and respiratory depression can also occur.
What this interaction means in plain words
Sufentanil and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sufentanil belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects, along with overlapping CNS depression.
What to do
Monitor for serotonin syndrome and excess sedation or respiratory depression, particularly in the perioperative setting. Stop the serotonergic agents and give supportive care if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Sufentanil with Venlafaxine?
MediHelp rates the interaction as moderate. Sufentanil and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is an opioid with some serotonergic potential, and serotonin syndrome has been reported with fentanyl-class opioids given with SNRIs. Additive sedation and respiratory depression can also occur.
How serious is the interaction between Sufentanil and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and excess sedation or respiratory depression, particularly in the perioperative setting. Stop the serotonergic agents and give supportive care if toxicity is suspected.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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