Drug interactions
Sufentanil sl + Tranylcypromine
Severity: Major
Sufentanil sl and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil in a patient on a nonselective MAOI may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Labeling advises against opioid use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Sufentanil sl and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may enhance serotonergic and opioid effects, with the exact mechanism not fully established.
What to do
Avoid combined use and allow 14 days after stopping tranylcypromine. Choose a non-opioid or alternative analgesic strategy and monitor respiration and mental status if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Sufentanil sl with Tranylcypromine?
MediHelp rates the interaction as major. Sufentanil sl and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil in a patient on a nonselective MAOI may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Labeling advises against opioid use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Sufentanil sl and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use and allow 14 days after stopping tranylcypromine. Choose a non-opioid or alternative analgesic strategy and monitor respiration and mental status if unavoidable.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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