Drug interactions
Sufentanil sl + Vecuronium
Severity: Moderate
Sufentanil sl and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is an opioid, and vecuronium causes paralysis without sedation, so they are not typical CNS depressant partners; in anesthesia they are routinely combined under ventilatory control. Outside a ventilated setting, paralysis combined with opioid respiratory depression is dangerous.
What this interaction means in plain words
Sufentanil sl and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opioid-induced respiratory depression combines with neuromuscular paralysis of respiratory muscles; vecuronium has no direct CNS effect.
What to do
Use only where airway control and mechanical ventilation are available, and titrate both agents to effect. Monitor ventilation and sedation closely during recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sufentanil sl and Vecuronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vecuronium
Frequently asked questions
Can I take Sufentanil sl with Vecuronium?
MediHelp rates the interaction as moderate. Sufentanil sl and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is an opioid, and vecuronium causes paralysis without sedation, so they are not typical CNS depressant partners; in anesthesia they are routinely combined under ventilatory control. Outside a ventilated setting, paralysis combined with opioid respiratory depression is dangerous.
How serious is the interaction between Sufentanil sl and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway control and mechanical ventilation are available, and titrate both agents to effect. Monitor ventilation and sedation closely during recovery.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
