Drug interactions
Sulfadiazine + Terbinafine
Severity: Minor
Sulfadiazine and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamides can inhibit CYP2C9, which in theory could modestly raise terbinafine levels. Terbinafine uses several clearance pathways, so a meaningful effect is unlikely.
What this interaction means in plain words
Sulfadiazine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfadiazine may weakly inhibit CYP2C9, one of several pathways involved in terbinafine metabolism.
What to do
No dose adjustment is required; be aware of the potential for increased terbinafine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Sulfadiazine with Terbinafine?
MediHelp rates the interaction as minor. Sulfadiazine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamides can inhibit CYP2C9, which in theory could modestly raise terbinafine levels. Terbinafine uses several clearance pathways, so a meaningful effect is unlikely.
How serious is the interaction between Sulfadiazine and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; be aware of the potential for increased terbinafine adverse effects.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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