Drug interactions
Sulfadiazine + Tolazamide
Severity: Moderate
Sulfadiazine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics such as sulfadiazine can potentiate sulfonylureas and cause hypoglycemia, sometimes severe. The risk is greater in elderly patients and those with renal or hepatic impairment.
What this interaction means in plain words
Sulfadiazine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfadiazine may displace tolazamide from plasma protein binding and inhibit its metabolism, raising free drug concentrations.
What to do
Monitor blood glucose closely during the antibiotic course and reduce the tolazamide dose if hypoglycemia develops. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Sulfadiazine with Tolazamide?
MediHelp rates the interaction as moderate. Sulfadiazine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics such as sulfadiazine can potentiate sulfonylureas and cause hypoglycemia, sometimes severe. The risk is greater in elderly patients and those with renal or hepatic impairment.
How serious is the interaction between Sulfadiazine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and reduce the tolazamide dose if hypoglycemia develops. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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