Drug interactions
Sulfamethoxazole + Tolazamide
Severity: Moderate
Sulfamethoxazole and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole can enhance the effect of sulfonylureas and has been associated with hypoglycemia, sometimes severe. Risk is higher in elderly patients and in renal impairment.
What this interaction means in plain words
Sulfamethoxazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfamethoxazole may displace the sulfonylurea from albumin and inhibit its CYP2C9-mediated metabolism, and it can itself stimulate insulin release.
What to do
Monitor blood glucose during co-trimoxazole therapy and lower the tolazamide dose if hypoglycemia occurs. Consider an alternative antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Sulfamethoxazole with Tolazamide?
MediHelp rates the interaction as moderate. Sulfamethoxazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole can enhance the effect of sulfonylureas and has been associated with hypoglycemia, sometimes severe. Risk is higher in elderly patients and in renal impairment.
How serious is the interaction between Sulfamethoxazole and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-trimoxazole therapy and lower the tolazamide dose if hypoglycemia occurs. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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