Drug interactions
Sulfamethoxypyridazine + Tolazamide
Severity: Moderate
Sulfamethoxypyridazine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This long-acting sulfonamide may potentiate tolazamide and lead to hypoglycemia. The interaction is inferred from other sulfonamide-sulfonylurea combinations.
What this interaction means in plain words
Sulfamethoxypyridazine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides can displace sulfonylureas from plasma proteins and may reduce their metabolism.
What to do
Monitor blood glucose during co-administration and reduce the tolazamide dose if hypoglycemia occurs. Educate the patient on symptoms of low blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Sulfamethoxypyridazine with Tolazamide?
MediHelp rates the interaction as moderate. Sulfamethoxypyridazine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This long-acting sulfonamide may potentiate tolazamide and lead to hypoglycemia. The interaction is inferred from other sulfonamide-sulfonylurea combinations.
How serious is the interaction between Sulfamethoxypyridazine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-administration and reduce the tolazamide dose if hypoglycemia occurs. Educate the patient on symptoms of low blood glucose.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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