Drug interactions
Sulfamethoxypyridazine + Tolbutamide
Severity: Moderate
Sulfamethoxypyridazine and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This long-acting sulfonamide may potentiate tolbutamide and increase the risk of hypoglycemia, by analogy with other sulfonamides.
What this interaction means in plain words
Sulfamethoxypyridazine and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely CYP2C9 inhibition and protein-binding displacement, as seen with other sulfonamides; not specifically established for this agent.
What to do
Monitor blood glucose during co-therapy and reduce the tolbutamide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Sulfamethoxypyridazine with Tolbutamide?
MediHelp rates the interaction as moderate. Sulfamethoxypyridazine and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This long-acting sulfonamide may potentiate tolbutamide and increase the risk of hypoglycemia, by analogy with other sulfonamides.
How serious is the interaction between Sulfamethoxypyridazine and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-therapy and reduce the tolbutamide dose if hypoglycemia develops.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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