Drug interactions
Sulfasalazine + Sulindac
Severity: Minor
Sulfasalazine and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a salicylate-containing agent that rarely causes blood dyscrasias, and sulindac can cause gastrointestinal and renal adverse effects. The combination offers little proven interaction beyond additive adverse effect risk.
What this interaction means in plain words
Sulfasalazine and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; possible additive GI irritation and hematologic or renal effects.
What to do
No routine adjustment is needed; monitor blood counts and renal function during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulfasalazine with Sulindac?
MediHelp rates the interaction as minor. Sulfasalazine and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is a salicylate-containing agent that rarely causes blood dyscrasias, and sulindac can cause gastrointestinal and renal adverse effects. The combination offers little proven interaction beyond additive adverse effect risk.
How serious is the interaction between Sulfasalazine and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood counts and renal function during long-term combined use.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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