Drug interactions
Sulfasalazine + Tolazamide
Severity: Moderate
Sulfasalazine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine may enhance the glucose-lowering effect of tolazamide, and hypoglycemia has been reported with sulfonylureas. The effect is generally modest.
What this interaction means in plain words
Sulfasalazine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; the sulfapyridine component may displace the sulfonylurea from protein binding or alter its metabolism.
What to do
Monitor blood glucose when starting or stopping sulfasalazine and reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Sulfasalazine with Tolazamide?
MediHelp rates the interaction as moderate. Sulfasalazine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine may enhance the glucose-lowering effect of tolazamide, and hypoglycemia has been reported with sulfonylureas. The effect is generally modest.
How serious is the interaction between Sulfasalazine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping sulfasalazine and reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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