Drug interactions
Sulfasalazine + Vancomycin
Severity: Minor
Sulfasalazine and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine contains a salicylate moiety, and a reduction in vancomycin clearance has been proposed, mainly in neonates. Evidence is weak and the practical relevance is small.
What this interaction means in plain words
Sulfasalazine and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction in vancomycin renal clearance; mechanism not established.
What to do
Monitor vancomycin trough levels and serum creatinine if both are used, particularly in neonates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Sulfasalazine with Vancomycin?
MediHelp rates the interaction as minor. Sulfasalazine and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine contains a salicylate moiety, and a reduction in vancomycin clearance has been proposed, mainly in neonates. Evidence is weak and the practical relevance is small.
How serious is the interaction between Sulfasalazine and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vancomycin trough levels and serum creatinine if both are used, particularly in neonates.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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