Drug interactions
Sulfisoxazole + Tolazamide
Severity: Moderate
Sulfisoxazole and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole can potentiate sulfonylurea action and cause hypoglycemia, particularly in elderly or renally impaired patients.
What this interaction means in plain words
Sulfisoxazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfisoxazole competes for plasma protein binding and may inhibit sulfonylurea metabolism, raising free tolazamide levels.
What to do
Monitor blood glucose during sulfisoxazole therapy and reduce the tolazamide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Sulfisoxazole with Tolazamide?
MediHelp rates the interaction as moderate. Sulfisoxazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole can potentiate sulfonylurea action and cause hypoglycemia, particularly in elderly or renally impaired patients.
How serious is the interaction between Sulfisoxazole and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfisoxazole therapy and reduce the tolazamide dose if hypoglycemia develops.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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