Drug interactions
Sulindac + Telmisartan
Severity: Major
Sulindac and Telmisartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the blood pressure lowering effect of angiotensin receptor blockers. In elderly, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Sulindac and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sulindac belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
NSAIDs block prostaglandin-mediated afferent arteriolar dilation while the ARB dilates the efferent arteriole, reducing glomerular filtration pressure; both also impair potassium excretion.
What to do
Ensure adequate hydration and monitor serum creatinine and potassium within the first weeks of combined use and after dose changes. Avoid the combination in patients with volume depletion or advanced renal disease where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Sulindac with Telmisartan?
MediHelp rates the interaction as major. Sulindac and Telmisartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the blood pressure lowering effect of angiotensin receptor blockers. In elderly, volume-depleted or renally impaired patients the combination can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Sulindac and Telmisartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine and potassium within the first weeks of combined use and after dose changes. Avoid the combination in patients with volume depletion or advanced renal disease where possible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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