Drug interactions
Sulindac + Tenofovir df
Severity: Moderate
Sulindac and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion, and NSAIDs can reduce renal blood flow and injure the kidney. Concurrent use, especially with high or repeated NSAID doses, has been associated with higher risk of renal impairment.
What this interaction means in plain words
Sulindac and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion adds to tenofovir proximal tubular toxicity and may reduce its clearance.
What to do
Use a non-NSAID analgesic where possible. If sulindac is required, use the lowest effective dose for a short period and monitor serum creatinine and eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Tenofovir df?
MediHelp rates the interaction as moderate. Sulindac and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by glomerular filtration and tubular secretion, and NSAIDs can reduce renal blood flow and injure the kidney. Concurrent use, especially with high or repeated NSAID doses, has been associated with higher risk of renal impairment.
How serious is the interaction between Sulindac and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-NSAID analgesic where possible. If sulindac is required, use the lowest effective dose for a short period and monitor serum creatinine and eGFR.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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