Drug interactions
Sulindac + Tenofovir disoproxil
Severity: Moderate
Sulindac and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac, like other NSAIDs, can impair renal perfusion and function, and tenofovir can cause proximal tubular injury. Concurrent use may increase the risk of renal impairment, especially with high doses, dehydration or existing kidney disease.
What this interaction means in plain words
Sulindac and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from NSAID-related reduction in renal prostaglandins and tenofovir tubular toxicity.
What to do
Consider non-NSAID alternatives. If combined, use the lowest effective NSAID dose briefly and monitor creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Sulindac and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac, like other NSAIDs, can impair renal perfusion and function, and tenofovir can cause proximal tubular injury. Concurrent use may increase the risk of renal impairment, especially with high doses, dehydration or existing kidney disease.
How serious is the interaction between Sulindac and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider non-NSAID alternatives. If combined, use the lowest effective NSAID dose briefly and monitor creatinine and phosphate.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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