Drug interactions
Sulindac + Ticarcillin
Severity: Moderate
Sulindac and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal clearance of penicillins and compete for protein binding, and ticarcillin can also impair platelet function. The pharmacokinetic effect is minor, but bleeding risk could be additive.
What this interaction means in plain words
Sulindac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for tubular secretion and additive platelet dysfunction (ticarcillin plus NSAID).
What to do
Monitor for bleeding and renal function, particularly with high-dose ticarcillin or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Ticarcillin?
MediHelp rates the interaction as moderate. Sulindac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce renal clearance of penicillins and compete for protein binding, and ticarcillin can also impair platelet function. The pharmacokinetic effect is minor, but bleeding risk could be additive.
How serious is the interaction between Sulindac and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function, particularly with high-dose ticarcillin or renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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