Drug interactions
Sulindac + Tobramycin inhaled
Severity: Moderate
Sulindac and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of inhaled tobramycin is low, but some patients, especially those with renal impairment, can accumulate it. NSAIDs can reduce renal function and increase aminoglycoside exposure and nephrotoxicity.
What this interaction means in plain words
Sulindac and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in renal perfusion and glomerular filtration may impair aminoglycoside elimination and add to nephrotoxicity.
What to do
Monitor serum creatinine and, if renal function declines, check serum tobramycin levels. Avoid the NSAID in patients with existing renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Sulindac and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic absorption of inhaled tobramycin is low, but some patients, especially those with renal impairment, can accumulate it. NSAIDs can reduce renal function and increase aminoglycoside exposure and nephrotoxicity.
How serious is the interaction between Sulindac and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and, if renal function declines, check serum tobramycin levels. Avoid the NSAID in patients with existing renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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