Drug interactions
Sulindac + Triamcinolone acetonide injectable
Severity: Moderate
Sulindac and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding. Systemic absorption from injectable triamcinolone is sufficient for this to matter, especially with repeated or high doses.
What this interaction means in plain words
Sulindac and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in patients at GI risk; counsel about GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Sulindac and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastrointestinal ulceration and bleeding. Systemic absorption from injectable triamcinolone is sufficient for this to matter, especially with repeated or high doses.
How serious is the interaction between Sulindac and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in patients at GI risk; counsel about GI bleeding symptoms.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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