Drug interactions
Sulindac + Venlafaxine
Severity: Moderate
Sulindac and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake and, with an NSAID, increases the risk of gastrointestinal and other bleeding. The risk is highest in older patients or those with a history of ulcers.
What this interaction means in plain words
Sulindac and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition reduces platelet aggregation, which adds to NSAID platelet inhibition and gastric mucosal injury.
What to do
Watch for bleeding signs such as melena, and consider gastroprotection with a proton pump inhibitor in at-risk patients. Limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sulindac and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Sulindac with Venlafaxine?
MediHelp rates the interaction as moderate. Sulindac and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake and, with an NSAID, increases the risk of gastrointestinal and other bleeding. The risk is highest in older patients or those with a history of ulcers.
How serious is the interaction between Sulindac and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for bleeding signs such as melena, and consider gastroprotection with a proton pump inhibitor in at-risk patients. Limit NSAID dose and duration.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
