Drug interactions
Sulindac + Willow bark
Severity: Moderate
Sulindac and Willow bark: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate, so combining it with an NSAID adds to NSAID effects, including gastrointestinal irritation and bleeding risk. This is a duplication of therapy rather than a transporter interaction.
What this interaction means in plain words
Sulindac and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition and antiplatelet effects from salicylate derived from willow bark.
What to do
Avoid using willow bark together with sulindac. Monitor for gastrointestinal bleeding and renal effects if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Willow bark?
MediHelp rates the interaction as moderate. Sulindac and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Willow bark contains salicin, which is converted to salicylate, so combining it with an NSAID adds to NSAID effects, including gastrointestinal irritation and bleeding risk. This is a duplication of therapy rather than a transporter interaction.
How serious is the interaction between Sulindac and Willow bark?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using willow bark together with sulindac. Monitor for gastrointestinal bleeding and renal effects if the combination is used.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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