Drug interactions
Sulphasalazine + Triamterene
Severity: Minor
Sulphasalazine and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic, and sulfasalazine has no meaningful potassium-raising action of its own. Any additive hyperkalemia is therefore not well supported, although sulfasalazine-related kidney injury could contribute in rare cases.
What this interaction means in plain words
Sulphasalazine and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sulphasalazine belongs to Gastrointestinal Tract; Triamterene belongs to Cardiovascular.
Why it happens
No established mechanism for additive hyperkalemia; triamterene blocks distal tubular sodium channels and so retains potassium, while sulfasalazine adds no direct effect.
What to do
No routine action is needed. Check serum potassium and renal function periodically in patients with renal impairment taking triamterene.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Sulphasalazine with Triamterene?
MediHelp rates the interaction as minor. Sulphasalazine and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamterene is a potassium-sparing diuretic, and sulfasalazine has no meaningful potassium-raising action of its own. Any additive hyperkalemia is therefore not well supported, although sulfasalazine-related kidney injury could contribute in rare cases.
How serious is the interaction between Sulphasalazine and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check serum potassium and renal function periodically in patients with renal impairment taking triamterene.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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