Drug interactions
Sumatriptan intranasal + Ziprasidone
Severity: Moderate
Sumatriptan intranasal and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has serotonin receptor activity and sumatriptan is a serotonin agonist, so serotonin syndrome is theoretically possible with combined use. Reports are rare, and intranasal sumatriptan is used intermittently.
What this interaction means in plain words
Sumatriptan intranasal and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity (5-HT1B/1D agonism with antipsychotic 5-HT receptor effects).
What to do
Counsel patients to seek care for agitation, tremor, fever, sweating or muscle rigidity after a dose. Monitor for serotonin toxicity when starting or increasing either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Sumatriptan intranasal with Ziprasidone?
MediHelp rates the interaction as moderate. Sumatriptan intranasal and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone has serotonin receptor activity and sumatriptan is a serotonin agonist, so serotonin syndrome is theoretically possible with combined use. Reports are rare, and intranasal sumatriptan is used intermittently.
How serious is the interaction between Sumatriptan intranasal and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek care for agitation, tremor, fever, sweating or muscle rigidity after a dose. Monitor for serotonin toxicity when starting or increasing either drug.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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