Drug interactions
Sunitinib + Trastuzumab
Severity: Moderate
Sunitinib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause cardiac toxicity, including reduced left ventricular ejection fraction. Concurrent use may add to the risk of cardiomyopathy and heart failure.
What this interaction means in plain words
Sunitinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive cardiotoxicity through different pathways (HER2 inhibition and VEGFR/other kinase inhibition).
What to do
Assess left ventricular ejection fraction at baseline and at regular intervals. Manage blood pressure and interrupt therapy if cardiac function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Sunitinib with Trastuzumab?
MediHelp rates the interaction as moderate. Sunitinib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause cardiac toxicity, including reduced left ventricular ejection fraction. Concurrent use may add to the risk of cardiomyopathy and heart failure.
How serious is the interaction between Sunitinib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular ejection fraction at baseline and at regular intervals. Manage blood pressure and interrupt therapy if cardiac function declines.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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