Drug interactions
Tacrine + Terbinafine
Severity: Minor
Tacrine and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrine is a CYP1A2 substrate and is not known to inhibit CYP1A2 meaningfully. A clinically relevant rise in terbinafine levels is not expected.
What this interaction means in plain words
Tacrine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; any effect would be via minor CYP1A2 competition.
What to do
No specific action needed; monitor for adverse effects of either drug as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Tacrine with Terbinafine?
MediHelp rates the interaction as minor. Tacrine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrine is a CYP1A2 substrate and is not known to inhibit CYP1A2 meaningfully. A clinically relevant rise in terbinafine levels is not expected.
How serious is the interaction between Tacrine and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed; monitor for adverse effects of either drug as usual.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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