Drug interactions
Tadalafil + Timolol
Severity: Minor
Tadalafil and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil may modestly add to the blood pressure lowering of systemic timolol. Clinically important hypotension is uncommon. Topical ophthalmic use has less systemic effect.
What this interaction means in plain words
Tadalafil and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tadalafil belongs to Genitourinary; Timolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from PDE5 inhibition and beta-blockade.
What to do
Monitor blood pressure when starting tadalafil with oral timolol. No dose adjustment is normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Tadalafil with Timolol?
MediHelp rates the interaction as minor. Tadalafil and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil may modestly add to the blood pressure lowering of systemic timolol. Clinically important hypotension is uncommon. Topical ophthalmic use has less systemic effect.
How serious is the interaction between Tadalafil and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting tadalafil with oral timolol. No dose adjustment is normally required.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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